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Wendsday 24 April 2024




Mostafa Shakhsi-niaei

Assistant Professor

Genetics

Basic Science Faculty

Tel: 03832324401

Shakhsi-Niaei.M@sci.sku.ac.ir

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Research Interest
   Target gene editing of Genetic diseases (Beta thalassemia) using CRISPR/CAS9:
   CAR-T Cell Therapy:
   Design and fabrication of diagnostic kits for viruses (VHSV, NDV, ...): This aim is following using biosensors or ARMS PCR
   Design and production of different recombinant vaccines for microbial infections or animal models induction (Multiple Sclerosis):
   Evolutionary genetics studies: Homeostasis genetic basis in different species

Academic Resume
   Phd, , University of Bern, Switzerland، Graduation Date: 2013
   Professional Phd, , shahrekord University, Iran، Graduation Date: 2008

Publications
International Journal
1. Mohammadreza Alijani a b, Behnaz Saffar c, Hossein Yosefi Darani d, Mohammadreza Mahzounieh e, Mahdi Fasihi- Ramandi f, Mostafa Shakshi-Niaei c, Sodabe Soltani g, Amir Ghaemi h, Sadegh Shirian, Immunological evaluation of a novel multi-antigenic DNA vaccine encoding SAG۱, SAG۳, MIC۴, GRA۵, GRA۷, AMA۱and BAG۱ against Toxoplasma gondii in BALB/c mice , ISI-JCR
2. Abbas Doosti*, Donya Kazemi, Mostafa Shakhsi-Niaei, The Decryption of Bab1 Brucella Abortus Antigen- Bcap31 Receptor Binding in Oral Lactococcus Lactis Vaccine and Its Effect on Activation of Casp-8 And Il-10 For Immunogenicity ,
3. Amirhossein Ghadiri, Abbas Doosti*, Mostafa Shakhsi-Niaei, Prevalence, antimicrobial susceptibility, and distribution of virulence genes involved in biofilm formation in multidrug-resistant Acinetobacter baumannii isolated from Shahrekord medical centers, Chaharmahal and Bakhtia , ISI-JCR
4. Ghazal Moattari, Zahra Izadi, Mostafa Shakhsi-Niaei, Development of an electrochemical genosensor for detection of viral hemorrhagic septicemia virus (VHSV) using glycoprotein (G) gene probe , Aquaculture
5. Mostafa Shakhsi-Niaei, Ehsan Heidari sureshjani, Ali Kazemi Babaheydari, In Silico Comparison of Separate or Combinatorial Effects of Po-tential Inhibitors of the SARS-CoV-۲ Binding Site of ACE۲ , Iran Journal of Public Health
6. Karim Mahnam, Mostafa Shakhsi-Niaei, Maryam Ziaei, Karen Sweazea, In silico evaluation of the downstream effect of mutated glucagon is consistent with higher blood glucose homeostasis in Galliformes and Strigiformes ,
7. Fatemeh Banisharif Dehkordi, Mohsen Mobini Dehkordi, Karim Mahnam, Mostafa Shakhsi-Niaei, Design and molecular dynamic simulation of a new double-epitope tolerogenic protein as a potential vaccine for multiple sclerosis disease , Research in Pharmaceutical Sciences
8. Fatemeh Mohammadi Milasi, Karim Mahnam, Mostafa Shakhsi-Niaei, In silico study of the association of the HLA-A*۳۱:۰۱ allele (human leucocyte antigen allele ۳۱:۰۱) with neuroantigenic epitopes of PLP (proteolipid protein), MBP (myelin basic protein) and MOG (Myelin oligodendrocyte glycoprotein) proteins , Journal of Biomolecular Structure and Dynamics
9. حامد حسینیان، کریم مهنام، مصطفی شخصی نیایی, The c.۳۰۵del۳ in IL-۲ gene in Homonoidea theoretically affects IL-۲/IL-۲Ra interaction as well as lymphocyte counts ,
10. Shakhsi-Niaei M1, Klukowska-Rötzler J, Drögemüller C, Swinburne J, Ehrmann C, Saftic D, Ramseyer A, Gerber V, Dolf G, Leeb T., Replication and fine-mapping of a QTL for recurrent airway obstruction in European Warmblood horses , Anim Genet. 2012 Oct;43(5):627-31
11. Mostafa Shakhsi-Niaei, Jolanta Klukowska-Rötzler, Cord Drögemüller, Vincent Gerber and Tosso Leeb, The equine DNAH3 gene: SNP discovery and exclusion of an involvement in recurrent airway obstruction (RAO) in European Warmblood horses , Arch Tierz 56 (2013) 1, 1-10 | 8 February 2013 | doi: 10.7482/0003-9438-56-001
12. Shakhsi-Niaei M1, Klukowska-Rötzler J, Drögemüller C, Swinburne JE, Gerber V, Leeb T., Characterization of the equine ITGAX gene and its association with recurrent airway obstruction in European Warmblood horses , Anim Genet. 2010 Oct;41(5):559-60.
13. نسرین پایاب، کریم مهنام، مصطفی شخصی نیایی, Computational Comparison of Two New Fusion Proteins for Multiple Sclerosis ,
14. Shakhsi-Niaei M, Drögemüller M, Jagannathan V, Gerber V, Leeb T., IL26 gene inactivation in Equidae , Anim Genet. 2013 Dec;44(6):770-2. doi: 10.1111/age.12069. Epub 2013 Jun 28.
15. الهام بنی مهدی، بهناز صفار، مصطفی شخصی نیایی, Y-Chromosomal status of six Indo-European-speaking Arab subpopulations in Chaharmahal and Bakhtiari Province, Iran ,
Research Journal
١٦. مریم محمدی دستنائی، عبدالکریم زمانی مقدم، مصطفی شخصی نیائی, تشخیص و تفسیر آسان، کم‌هزینه و دقیق ویروس نیوکاسل و تفریق سویه حاد از غیرحاد با روش RT-ARMS PCR آشیانه‌ای , Accepted to Online Publish
١٧. شیما رحیمی راد، رسول صالحی، بهناز صفار، مصطفی شخصی نیایی, بررسي فراواني نسبي پلي مورفيسم تک نوکلئوتيدي (G۸۷۰A (rs۹۳۴۴ در ژن (CyclinD۱ (CCND۱ در بيماران مبتلا به سرطان کلورکتال و افراد سالم در جمعيت اصفهان ,
١٨. الهام الهی نژاد، حسین مهربان، مصطفی شخصی نیایی, برآورد صحت ارزش هاي اصلاحي صفات پيچيده در جوامع بدون شجره با استفاده از نشانگرهاي متراکم ,
International Conference
١٩. طاهره کریمی شایان، ولی اله خلجی پیربلوطی، مصطفی شخصی نیایی, بررسي هموستاز گلوکزبا استفاده از تست خوراکي تحمل گلوکز در شترمرغ (Struthio camelus) ,



Books



Honors



Thesis
Number Student Name Title Defence Date
1. ُSaba vahhabi Evaluation of MMP-9 gene expression in inhibited mouse model of experimental autoimmune encephalitis (EAE) by cyclosporine A and Bioinformatics evaluation of its gene regulatory network یکشنبه ٢٦ شهريور ١٤٠٢
2. Armita Kiani Evaluation of the effect of a plasmid encoding recombinant toxin ImKTx88 from scorpion on inhibition of induction and IL-18 expression in the brain of an EAE mice شنبه ٢٤ تیر ١٤٠٢
3. Farahnaz Johari Evaluation of the effect of a eukaryotic plasmid encoding scFv of Brodalumb antibody in alteration of the expression of downstream IL-17C signaling pathway genes (TNF-? and IL-1?) in THP-1 cells یکشنبه ١٨ تیر ١٤٠٢
4. Parastoo Tabaeian Replacement of the variable domain of sheep SLAM with cat and their cloning into pEGFP-N1 جمعه ١ فروردين ١
5. Misagh Saberian Effect of an eukaryotic vector expressing ImkTX88 toxins on mice model of experimental autoimmune encephalomyelitis (EAE) جمعه ١ فروردين ١
6. Fatemeh Reshadi Evaluation of the effect of injection of an EAE-inducing eukaryotic plasmid in combination with oral ginger extract administration in induction of tolerance in mice جمعه ١ فروردين ١
7. Fatemeh Dashti Comparison of genes involved in blood glucose homeostasis system between Gallus gallus and Gallus varius جمعه ١ فروردين ١
8. Maryam Mousavi Evaluation of the effect of injection of an EAE-inducing eukaryotic plasmid in combination with cyclosporine in induction of tolerance in mice جمعه ١ فروردين ١
9. Nikoo Esmaeili Prediction of Peptide Complex T-Lymphocyte Receptor Sequences: HLA-A * 03 Using Supervised Machine Learning Methods جمعه ١ فروردين ١
10. Bahar Ataei Co-transfection of two different CRISPR/Cas9 vectors containing two specific gRNAs for deletion of corresponding fragment including IVS-II-1(G>A ) mutation in HBB gene in HDF cell line جمعه ١ فروردين ١
11. Shima Rahimi Rad Studing of The relative Frequency of single nucleotide polymorphism G870A in the gene CyclinD1 (CCND1) in patients with colorectal cancer Referred to Seyedalshohada hospital of isfahan چهارشنبه ١٠ تیر ١٣٩٤
12. Armin Barati Boroujeni Evaluation of IL-10 expression related to autoimmune M.S. disease in the presence of Chamomile extract in cell culture using Real-time RT-PCR دوشنبه ٢٦ مهر ١٣٩٥
13. Armin Barati Boroujeni Evaluation of IL-10 expression related to autoimmune M.S. disease in the presence of Chamomile extract in cell culture using Real-time RT-PCR دوشنبه ٢٦ مهر ١٣٩٥
14. Elham Elahi Nejad Estimating the Accuracy of Genomic Evaluation Methods in Complex Traits (A Simulation Study) چهارشنبه ١٨ اسفند ١٣٩٥
15. Elham Elahi Nejad Estimating the Accuracy of Genomic Evaluation Methods in Complex Traits (A Simulation Study) چهارشنبه ١٨ اسفند ١٣٩٥
16. Nasrin Payab Theoretical design of vaccine for Multiple sclerosis(MS) disease based on epitopes MOG(1-20), MOG(11-30), MBP(13-32) and MBP(111-129) چهارشنبه ١٨ اسفند ١٣٩٥
17. Sadegh Matin Ghahfarrokhi Evaluation of the Allelic frequency of BoLA-DRB3.2 gene in the seropositive cattle infected with bovine leukemia virus شنبه ١١ آذر ١٣٩٦
18. Mohammad Kazam Momeni Cloning and surface display of Kluyveromyces beta-galactosidase to Saccharomyces cerevisiae شنبه ٢٥ شهريور ١٣٩٦
19. Zahra Ghobadi Theoretical Design of Binding Peptide to HLA-A*03 Allele in order prevention Cytotoxic T- cells Binding; as a Potential Drug for MS Disease چهارشنبه ٣٠ بهمن ١٣٩٨
20. Elham Banimehdi Dehkordi Investigation of Seyyid haplogroup and its subtypes in Chaharmahal and Bakhtiari Province سه شنبه ٢٨ مهر ١٣٩٤
21. Tahereh Karimi Shayan Structural analysis of insuline sensitive glucose transporters 4 and 12 in physiologic hyperglycemiain ostrich سه شنبه ٥ آبان ١٣٩٤
22. Fatemeh Banisharif Dehkordi Design and cloning of a tolerogenic vaccine based on fusion proteins of neuroantigens for MS protection چهارشنبه ١٩ اسفند ١٣٩٤
23. Roksaneh Sayyadi Borujeni Design and cloning of a DNA-vaccine against viral hemorrhagic septicemia (VHS) disease in Saccharomyces cerevisiae سه شنبه ١٣ تیر ١٣٩٦
24. Sudabeh Soltani production of multi-stage DNA vaccine against the Toxoplasma gondii پنج شنبه ٣٠ شهريور ١٣٩٦
25. Fatemeh Mohammadi Milasi Prediction of the MOG Neuroantigenic Epitopes and Investigation of their Binding to HLA-A*31:01 Allele by Molecular Dynamics Simulation Method سه شنبه ٢٥ مهر ١٣٩٦
26. Narjes Farajzadeh Dehkordi Dsign construction and cloning of MHC I with the ability to multimerization with the aim of producing specific Peptide: MHC associated with multiple sclerosis یکشنبه ٣٠ مهر ١٣٩٦
27. Ahmad Rahimi Taghanaki Investigation of deletion of a fragment including IVS-II-1 mutation from HBB gene by CRISPR/Cas9 tool for correction of compromised splicing سه شنبه ٢٠ شهريور ١٣٩٧
28. Maryam Mohammadi Dastenaei Rapid detection of chicken Newcastle virus and distinguishing velogenic from lentogenic variants by RT-ARMS-PCR یکشنبه ١٩ اسفند ١٣٩٧
29. Seyed Javad Rajaei Investigation of the frequency of HLA-A02, A03, A11, A24 and A31 associated alleles with multiple sclerosis in patients referred to MS clinic center in Isfahan province by Nested-SSP-PCR جمعه ١٥ شهريور ١٣٩٨
30. Ghazal Moattari Fabrication and fanctional evaluation of a Gold/Graphene nanocomposite based electroclemical biosensor for detection of VHS virus سه شنبه ٢٦ شهريور ١٣٩٨
31. Mahdi Rahimpour Design, synthesizing and cloning of equine follicle stimulating hormone in Saccharomyces cerevisiae یکشنبه ٣١ شهريور ١٣٩٨
32. Bahare Nikoozar Subcloning and expression of recombinant HLA-A*31:01 for experimental investigation of its interaction with neuroantigenic epitope of MOG:195-204 یکشنبه ٢٠ بهمن ١٣٩٨






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